TIVA PK Simulator

Patient Covariates

Sex

Age yr

Weight kg

Height cm

Propofol Concentration

Dosing Mode

Bolus Dose mg

Push Rate cc/hr

Target Ce Band (μg/mL)

Lower

Upper

Time Range

BIS Correlation (Eleveld 2018)

Ce → Predicted BIS

Schnider Ce@5min

Marsh Ce@5min

BIS 60 threshold Ce

BIS 40 threshold Ce

Key Values

Schnider

Cp @ 5 min—

Ce @ 5 min—

Cp Peak—

Css—

Marsh

Cp @ 5 min—

Ce @ 5 min—

Cp Peak—

Css—

Combined View Model

Select:

Schnider Cp

Schnider Ce

Marsh Cp

Marsh Ce

Target Band

BIS(Schnider)

BIS(Marsh)

— BIS 60

— BIS 40

Patient Covariates

Sex

Age yr

Weight kg

Height cm

Remifentanil Concentration

Dosing Mode

① Initial infusion

Initial Rate cc/hr

Duration min

② New infusion rate

New Rate cc/hr

Target Ce Band (ng/mL)

Lower

Upper

Time Range

Key Values

Minto 1997

LBM—

ke0—

Cp @ 5 min—

Ce @ 5 min—

Cp Peak—

Css—

Cp (plasma)

Ce (effect-site)

Target Band

Patient Covariates

Sex

Age yr

Weight kg

Concomitant Opioids

OFF

Solution Concentration

Dosing Mode

① Initial infusion

Initial Rate mL/hr

Duration min

② New rate

New Rate mL/hr

Target Ce Band (ng/mL)

Lower

Upper

Time Range

BIS Correlation (Eleveld 2025)

Ce → Predicted BIS

Eleveld Ce@30min—

Zhou Ce@30min—

BIS≤60 threshold Ce —

BIS≤40 threshold Ce —

Key Values

Eleveld 2025

ke0—

Cp @ 5min—

Ce @ 5min—

Cp Peak—

Css—

Zhou 2020

ke0—

Cp @ 5min—

Ce @ 5min—

Cp Peak—

Css—

Combined View Model

Select:

Eleveld Cp

Eleveld Ce

Zhou Cp

Zhou Ce

Target Band

Propofol: Schnider | Remifentanil: Minto | Remimazolam: Eleveld

Sex: M Age: 50 yr Wt: 70 kg Ht: 170 cm

● Propofol Continuous 60 cc/hr Ce 2–4 μg/mL Cp@5min: — | Ce@5min: — | Css: —

● Remifentanil Continuous 20 cc/hr Ce 2–5 ng/mL Cp@5min: — | Ce@5min: — | Css: —

● Remimazolam Continuous 12 mL/hr Ce 650–1300 ng/mL Cp@5min: — | Ce@5min: — | Css: —

Time Range